aluminium chloride hexahydrate solubility

24 h after administration, the animals were killed, bone marrow slides were prepared and evaluated for micronucleus frequency. 77, No. Aluminum chloride hexahydrate, JIS special grade, >=98.0%. Under the test conditions, repeated oral administration of aluminium chloride was reported to induce a statistically significant increase in the number of micronucleated hepatocytes. On top of that, cytotoxicity was not assessed and no positive control was used. were seen in the NOTOX study from 2007, despite the fact the animals in this study were repeatedly treated with much higher aluminium doses for a much longer time. Also, the liver cannot be used as a target tissue for the micronucleus assay in adult rats: in this study, 8-weeks old adult rats have been treated for 30 days which means they were 12-weeks old at termination. Welcome to the ECHA website. Test concentrations used were between 20 - 5000 ug/plate. It is highly soluble in water and also soluble in alcohol, ether, glycerol, propylene glycol and acetonitrile. at dose-levels of 0.01, 0.05 and 0.1 M. Bone marrow cells of specimens at 0.1 M were fixed at 1, 2, 4, 8, 12, 16, 20, 24, 48 and 72 h after the injection while those of 0.01 and 0.05 M series were fixed at 20 h only after the injection. RBC, WBC, PLT, Hb and Ht revealed significant decreases in the Al treated group compared to the control. Reproduction of any materials from the site is strictly forbidden without permission. They consist of aluminium and chlorine atoms in a 1:3 ratio, and one form also contains six waters of hydration. In the study, aluminium chloride induced a statistically significant increase in the numbers of micronucleated hepatocytes. At the end of the experiment, rats were sacrificed and hepatocytes (HEP) were isolated for counting the number of micronucleated hepatocytes (MNHEPs). Moreover, the volume administered intraperitoneally was 3.3 mL/100 g bodyweight which clearly exceeds the recommended limit volume of 2 mL/100 g bodyweight. Aluminium chloride is mainly produced using an exothermic reaction of two elements namely aluminium and chlorine. Also, the OECD guideline 475 recommends the analysis of at least 100 cells/animal : in this study, there were supposed to be 4 mice per group and 200 cells per group, therefore potentially only 50 cells analysed per animal, but in some cases even 200 cells could not be analysed, which suggests a serious problem with the quality and number of metaphases studied. A fritted glass filter, B, fused on a 6-mm-OD Pyrex tube is joined to an outer tube attached to two Teflon stopcocks, D and E. The top assembly is attached to A at C by a threaded nylon compression fitting with a neoprene 0-ring. Aluminum chloride can stimulate neurofibrillary changes in neurons of spinal cord and cerebrum in the developing rabbit′s brain. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 09/27/2007 Revision date: 06/20/2013 Supersedes: 02/10/2011 Version: 1.0 06/20/2013 EN (English) Page 1 Moreover, simultaneous treatment with propolis significantly modulated the toxic effects of, were intraperitoneally administered basic aluminium chloride at 5 mg/kg bw/day for 10 weeks. to you upon submission of this form. 6H2O. (2007) reported an in vitro mammalian chromosome aberration assay. All tested concentrations were cytotoxic, far beyond the range recommended in OECD guideline 473, and reduced significantly the mitotic index in all phases of cell cycle. At the end of the experiment, rats were sacrificed and hepatocytes (HEP) were isolated for counting the number of micronucleated hepatocytes (MNHEPs). The results are therefore considered unsuitable to assess a chromosome aberration potential of the test compound, and the study was assigned a Klimisch rating of 3 and disregarded. 62K1064 – you will only find the COO if Anhydrous aluminium chloride was found to be non-mutagenic with and without metabolic activation. Cells were treated with different doses of aluminium chloride (1, 2, 5, 10, and 25 µg/mL) for 72 h. Results indicated that Al induces DNA damage in a dose-dependent manner, however, at the dose of 25 µg/mL the level of damage declined. All in all, it is very likely that the observed effects are not related to test substance exposure but were present in all animals (from treated and control groups) already before substance administration. There are several other ways in which aluminium chloride can be obtained. Lankoff et al. © 2020  Merck KGaA, Darmstadt, Germany and/or its affiliates. However, this study was diregarded because of the following main limitations: Significant damage in the liver was reported (increase in levels of serum enzymes and histological alterations in liver) whereas in a GLP OECD guideline 422 study on AlCl basic (CAS 1327-41-9), no liver damage and reduced ALP activity were observed up to 1000 mg/kg/day. H��W]s�8|W��=WC H���Jk;o]윭��V��DۼP�W�������%��U^l���`������|ۍ��͇Ӌ�q:���_�N�6�e6z3��c3�ݍʤ�/���Kr;.l��eƳ�(�o��ћ_o����I�z���O���j��V��ޭ��z���ˤPO˭6ebՆ�'���^jO_+=q�W'�6+�F������% �IP���;m-��Km�:O25�)-�l7�Ǯެ���p0+sY�K����8��aV���'N]kk������Hi���������������,��QI�[��F1a�'�������v��Fw�?G��r���8�E�{J�b5zs�����?�I^X�Bj2��ؼ���kN Eh������8D����2 ����ҳ�`��ib��(_��`�I��ڢ����Y�M31�/�"J����w[f�$��S'6*�#Ja��=PY��z���=�f=p�Q��A�C&�/��JiYĥ���Z�Iv�Q�p��v�U�)�4#Y�y�1+s�mH�>E^�J��ڏD��T*/�Z�� ��*)ȩ�����7[�L5!�P�F���G���Yݶ��6���昜2�b�{�˃�#��^Y��GБ�j�+���~�8��؄h��b���'��M�%������2���j�f��S�3��ی(���Ȝb��2��ϥ�: X�l��2�a]L��qT0���Q*�Txm�_���[email protected]���/ݶ^ s^��)7� All tested concentrations were cytotoxic, far beyond the range recommended in OECD guideline 473, and reduced significantly the mitotic index in all phases of cell cycle. Test concentrations used were between 20 - 5000 ug/plate. Basic aluminium chloride was tested in a GLP-compliant in vitro micronucleus assay conducted according to OECD guideline 487 (NOTOX, 2010). The substances are listed in alphabetical order. K9. Under the test conditions, AlCl3 was considered to induce chromosomal aberrations at higher concentrations. following the words 'Lot' or 'Batch'. Mouse lymphoma L5178Y cells were used. number 09019TO without the first two letters. Some common ways are by reacting aluminium metal with hydrogen chloride or by conducting a single displacement reaction between copper chloride and aluminium metal. Contents A Aluminum chloride can stimulate neurofibrillary changes in neurons of spinal cord and cerebrum in the developing rabbit′s brain. Incompatible with acids.Note that decomposition of the anhydrous product, possibly caused by moisture leakinginto the container or being Molarity Calculator & Normality Calculator for Acids & Bases. Please upgrade your Internet Explorer to a newer version. treated up to 2000 mg/kg/day (the maximum recommended dose for this study). A mutagenic potential was not identified in this study. The study has several severe deficiencies making it unreliable: Positive control results were originally not reported and only delivered upon request, and no historical control data are reported. Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, ACD/Labs Percepta Platform - PhysChem Module, Compounds with the same molecular formula, Search Google for structures with same skeleton, Soluble in water , alcohol, ether, glycerol, propylene glycol.

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