According to the results of NGS and clinical manifestation of the patient, we judged that A. baumannii was the main pathogen, and this A. baumannii strain was susceptible to imipenem which was confirmed by subsequent antibiotic susceptibility results (Table 2). Community-acquired pneumonia caused by A. baumannii (CAP-Ab) is rare. 2008;358(12):1271–81. Expert Rev Anti Infect Ther. 2012;7(10):e46984. Community-acquired pneumonia caused by Acinetobacter baumannii (CAP-Ab) is rare but fatal if diagnosis and treatment are delayed. Davis JS, McMillan M, Swaminathan A, et al. Curr Opin Infect Dis. He was diagnosed as severe community acquired pneumonia (CAP), septic shock, respiratory failure and acute kidney injury. Springer Nature. However, CAP-Ab progresses more rapidly and is associated with a higher mortality compared to HAP caused by A. baumannii . MML participated in the treatment of the patient during hospitalization, HXW and ZND collected and analyzed the medical data. Wilson MR, Naccache SN, Samayoa E, et al. J Clin Virol. Background: En service de réanimation, on l’isolait dans 5 % des infections pulmonaires. Cite this article. 2015 May;13(5):567-73. doi: 10.1586/14787210.2015.1025055. Epub 2018 Sep 12. The mortality rate of CAP-Ab is high (40–64%) , but, it’s reported that if early effective antibiotics against A. baumannii were used, the mortality rate can be reduced to only 11% . Author information: (1)Intensive Care Clinical Unit, Hospital Universitario Virgen Macarena. Part of However, he said that he had a 50-year history of cigarette smoking and alcohol ingestion and had not quit before being sent to our hospital. Chin Med J. Genome Med. N Engl J Med. Community-acquired pneumonia caused by Acinetobacter baumannii (CAP-Ab) is rare but fatal if diagnosis and treatment are delayed. 2015;13(5):567–73. Acinetobacter infection. Rapid detection and identification of infectious pathogens based on high-throughput sequencing. Ni PX, Ding X, Zhang YX, et al. Acinetobacter baumannii est une bactérie à Gram-négatif du genre Acinetobacter. d The patient was extubated. This pathogen is the most frequently isolated species (>90 percent of Acinetobacter spp isolates) and is typically associated with outbreaks in the hospital setting. 2018;18(1):379. Under such circumstances, the implementation of NGS in clinical field has great guiding value for the diagnosis and treatment of infectious diseases. Keywords: Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. Currently, Nucleic acid amplification tests (NAATs) methods for the rapid detection of major pathogens responsible for serious morbid conditions are commercially available in microbiological laboratory diagnostics. Il a aussi été isolé du sol et de l'eau dans l'environnement. Acinetobacter can colonize skin, wounds, and the respiratory and gastrointestinal tracts. Severe community-acquired pneumonia caused by Acinetobacter baumannii successfully treated with the initial Administration of Meropenem Based on the sputum gram staining findings. This result was confirmed by subsequent sputum culture. Thereafter, the patients’ respiratory condition gradually improved. Severe Community-acquired Pneumonia Caused by Acinetobacter baumannii Successfully Treated with the Initial Administration of Meropenem Based on the Sputum Gram Staining Findings. Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
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